Scientist, Bioinformatics

Scientist, Bioinformatics

Bridging the gap between Genomics and Data Science

Publications

Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line

Published in Stem Cells Translational Medicine, 2025

Disease modeling using iPSC

Recommended citation: Dinasarapu AR , Sutcliffe DJ, Ozel E, Thite A, Grychowski L, Visser JE, Hess EJ, Kolk SM, Jinnah HA, Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line, Stem Cells Translational Medicine, 14, 12, 2025. https://doi.org/10.1093/stcltm/szaf065

Modeling rare genetic disease with patient-derived induced pluripotent stem cells: reassessment of the minimum numbers of lines needed

Published in Stem Cells Translational Medicine, 2025

Disease modeling using iPSC

Recommended citation: Dinasarapu AR , Sutcliffe DJ, Grychowski L, Ozel E, Thite A, Visser JE, Hess EJ, Kolk SM, Jinnah HA, Modeling rare genetic disease with patient-derived induced pluripotent stem cells: reassessment of the minimum numbers of lines needed, Stem Cells Translational Medicine, 14, 8, 2025. https://doi.org/10.1093/stcltm/szaf032

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.

Published in Cancer Research, 2024

Recommended citation: Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H,Zhou W, Marcus AI, Gilbert-Ross M. (2023) Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer" https://doi.org/10.1158/0008-5472.can-23-2631

Chronic SIV-induced neuroinflammation disrupts CCR7+CD4+ T cell immunosurveillance in the rhesus macaque brain.

Published in Journal of Clinical Investigation, 2024

Infectious diseases & Inflammation

Recommended citation: Elizaldi SR, Hawes CE, Verma A, Shaan Lakshmanappa Y, Dinasarapu AR, Schlegel BT, Rajasundaram D, Li J, Durbin-Johnson BP, Ma ZM, Pal PB, Beckman D, Ott S, Raeman R, Lifson J, Morrison JH, Iyer SS (2024). Chronic SIV-induced neuroinflammation disrupts CCR7+CD4+ T cell immunosurveillance in the rhesus macaque brain. J Clin Invest. https://pubmed.ncbi.nlm.nih.gov/38470479/

Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana.

Published in Retrovirology, 2022

Infectious diseases & Inflammation

Recommended citation: Yin L, Dinasarapu AR , Borkar SA, Chang KF, De Paris K, Kim-Chang JJ, Sleasman JW, Goodenow MM (2022) Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana" Retrovirology 19, 10 (2022) https://retrovirology.biomedcentral.com/articles/10.1186/s12977-022-00594-4

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.

Published in Journal of Neuroinflammation, 2022

Infectious diseases & Inflammation

Recommended citation: Hawes CE, Elizaldi SR, Beckman D, Diniz GB, Lakshmanappa YS, Ott S, Durbin-Johnson BP, Dinasarapu AR , Gompers AL, Morrison JH, Iyer SS (2022). Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection. Journal of Neuroinflammation, 19, 250. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02610-y

Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection.

Published in FEBS Letters, 2021

Infectious diseases

Recommended citation: Lakshmanappa YS, Roh JW, Rane NN, Dinasarapu AR , Tran DD, Velu VV, Sheth AN, Ofotokun I, Amara RR, Kelley CF, Waetjen EW, Iyer SS (2021) Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection" FEBS Letters. 595(17):2257-2270. https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14163

Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease.

Published in medRxiv, 2021

Functional Genomics

Recommended citation: Chakravorty S, Berger L, Rufibach L, Gloster L, Emmons A, Shenoy S, Hegde M, Dinasarapu AR, Gibson G (2021) Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease." medRxiv https://doi.org/10.1101/2021.01.14.21249850

Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.

Published in Molecular Genetics and Metabolism, 2021

Neuroscience

Recommended citation: Briscione MA, Dinasarapu AR, Bagchi P, Donsante Y, Downs AM, Fan X, Hoehner J, Jinnah HA, Hess EJ (2021). "Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders." Molecular Genetics and Metabolism. 133(4):352-361. https://doi.org/10.1016/j.ymgme.2021.05.010

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).

Published in PLOS ONE, 2020

Cancer Genomics

Recommended citation: Nabil F. Saba NF*, Dinasarapu AR*, Magliocca KR, Dwivedi B, Seby S, Qin ZS, Patel M, Griffith CC, Wang X, El-Deiry M, Steuer CE, Kowalski J, Shin DM, Zwick ME, Chen ZG (2020). "Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)." PLOS ONE 15(9): e0238497. https://doi.org/10.1371/journal.pone.0238497