Blood-Based Proteomics for Adult-Onset Focal Dystonias.
Timsina J, Dinasarapu AR , Kilic-Berkmen G, Budde J, Sung YJ, Klein AM, Cruchaga C, Jinnah HA (2024) Blood-Based Proteomics for Adult-Onset Focal Dystonias. Annals of Neurology, (2024)
Education
- Ph.D. Biochemistry/Bioinformatics, University of Hyderabad, India 2007
- M.Tech. Biotechnology, Anna University, India 2002
- M.Sc. Biochemistry, University of Hyderabad, India 2000
- B.S. Chemistry & Biology, Andhra Loyola College, India 1997
Work experience
- 10/2017-till: Scientist, Bioinformatics
- Emory University, Atlanta
- Duties included: Genomic, Proteomic and Lipidomic data analysis
- Supervisors:
Hyder A. (Buz) Jinnah, MD& Mike Zwick Ph.D
- 09/2015-10/2017: Bioinformatics Analyst, Sr
- Emory University, Atlanta
- Duties included: Genomic data analysis
- Supervisors: Bali Pulendran Ph.D &
Mike ZwickPh.D
- 11/2013-09/2015: Postdoctoral Associate
- University of Florida, Gainesville
- Duties included: Microarray data analysis
- Supervisor:
Maureen GoodenowPh.D
- 03/2008-11/2013: Postdoctoral Fellow
- University of California San Diego
- Duties included: Microarray and Lipidomic data analysis
- Supervisor:
Shankar SubramaniamPh.D
Skills
- NGS, Proteomics and Lipidomics
- Cluster and Cloud computing
- Linux shell
- R for Statistical Computing
- Python
- Java/J2EE
Publications
Chronic SIV-induced neuroinflammation disrupts CCR7+CD4+ T cell immunosurveillance in the rhesus macaque brain.
Elizaldi SR, Hawes CE, Verma A, Shaan Lakshmanappa Y, Dinasarapu AR, Schlegel BT, Rajasundaram D, Li J, Durbin-Johnson BP, Ma ZM, Pal PB, Beckman D, Ott S, Raeman R, Lifson J, Morrison JH, Iyer SS (2024). Chronic SIV-induced neuroinflammation disrupts CCR7+CD4+ T cell immunosurveillance in the rhesus macaque brain. J Clin Invest.
Exploration of potential immune mechanisms in cervical dystonia
Scorr LM, Kilic-Berkmen G, Sutcliffe DJ, Dinasarapu AR , McKay JL, Bagchi P, Powell MD, Boss JM, Cereb N, Little M, Gragert L, Hanfelt J, McKeon A, Tyor W, Jinnah HA (2024) Exploration of potential immune mechanisms in cervical dystonia. Parkinsonism & Related Disorders (2024)
An Exploratory, Randomized, Double-Blind Clinical Trial of Dipraglurant for Blepharospasm
Kilic-Berkmen G, Kim H, Chen D, Yeo CI, Dinasarapu AR , Scorr LM, Yeo WH, Peterson DA, Williams H, Ruby A, Mills R, Jinnah HA (2024) An Exploratory, Randomized, Double-Blind Clinical Trial of Dipraglurant for Blepharospasm. Movement Disorders (2024)
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.
Roman KM, Dinasarapu AR ,VanSchoiack A, Ross PM, Kroeppler D, Jinnah HA,Hess EJ (2023). Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum. Cell Reports.
Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H,Zhou W, Marcus AI, Gilbert-Ross M. (2023) Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer"
Abnormalities of Neural Stem Cells in Lesch-Nyhan Disease.
Dinasarapu AR , Sutcliffe DJ, Seifar F, Visser JE, Jinnah HA (2022). Abnormalities of Neural Stem Cells in Lesch-Nyhan Disease. Journal of Neurogenetics. 2022;36(2-3):81-87.
Uric Acid in Parkinson’s Disease: What Is the Connection?
Seifar F, Dinasarapu AR , Jinnah HA (2022) Uric Acid in Parkinsons Disease: What Is the Connection Movement Disorders (2022)
Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana.
Yin L, Dinasarapu AR , Borkar SA, Chang KF, De Paris K, Kim-Chang JJ, Sleasman JW, Goodenow MM (2022) Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana" Retrovirology 19, 10 (2022)
Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.
Hawes CE, Elizaldi SR, Beckman D, Diniz GB, Lakshmanappa YS, Ott S, Durbin-Johnson BP, Dinasarapu AR , Gompers AL, Morrison JH, Iyer SS (2022). Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection. Journal of Neuroinflammation, 19, 250.
Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection.
Lakshmanappa YS, Roh JW, Rane NN, Dinasarapu AR , Tran DD, Velu VV, Sheth AN, Ofotokun I, Amara RR, Kelley CF, Waetjen EW, Iyer SS (2021) Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection" FEBS Letters. 595(17):2257-2270.
Induced Pluripotent Stem Cells from Subjects with Lesch-Nyhan Disease.
Sutcliffe DJ*, Dinasarapu AR *, Visser JE, Hoed JD, Seifar F, Joshi P, Ceballos-Picot I, Sardar T, Hess EJ, Sun YV, Wen Z, Zwick ME, Jinnah HA (2021) Induced Pluripotent Stem Cells from Subjects with Lesch-Nyhan Disease" Scientific Reports 11, 8523 (2021)
Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease.
Chakravorty S, Berger L, Rufibach L, Gloster L, Emmons A, Shenoy S, Hegde M, Dinasarapu AR, Gibson G (2021) Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease." medRxiv
Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.
Briscione MA, Dinasarapu AR, Bagchi P, Donsante Y, Downs AM, Fan X, Hoehner J, Jinnah HA, Hess EJ (2021). "Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders." Molecular Genetics and Metabolism. 133(4):352-361.
Autoimmune and Inflammatory Mechanisms in Cervical Dystonia.
Kilic-Berkmen G, Scorr L, Dinasarapu AR, McKay L, Rosen A, Bagchi P, Hanfelt J, McKeon A, Jinnah HA (2020) Autoimmune and Inflammatory Mechanisms in Cervical Dystonia." medRxiv
Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).
Nabil F. Saba NF*, Dinasarapu AR*, Magliocca KR, Dwivedi B, Seby S, Qin ZS, Patel M, Griffith CC, Wang X, El-Deiry M, Steuer CE, Kowalski J, Shin DM, Zwick ME, Chen ZG (2020). "Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)." PLOS ONE 15(9): e0238497.
Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.
Verma A, Schmidt B, Nguyen N, Elizaldi S, Walter K, Beck Z, Trinh H, Dinasarapu AR, ... and Iyer SS. (2020). "Impact of Th1 CD4 TFH skewing on antibody responses to an HIV-1 vaccine in Rhesus Macaques." Journal of Virology, 94 (6) e01737-19.
Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques.
Elizaldi SR, Verma A, Walter KA, Rolston M, Dinasarapu AR, Durbin-Johnson BP, Settles M, Kozlowski PA, Raeman R and Iyer SS. (2019). "Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques." mSphere, 4:e00824-19.
Modeling DYT1 Dystonia Using Induced Pluripotent Stem Cells.
Dinasarapu AR, DJ Sutcliffe, ME Zwick, HA Jinnah. (2018). "Modeling DYT1 Dystonia Using Induced Pluripotent Stem Cells." Annals Of Neurology, 84, S198-S199.
Disease Modeling of Lesch-Nyhan Disease Using Induced Pluripotent Stem Cells.
Sutcliffe D, Dinasarapu A, Zwick M, Jinnah H (2018). "Disease Modeling of Lesch-Nyhan Disease Using Induced Pluripotent Stem Cells." MOVEMENT DISORDERS, 33.
Biological data integration and dissemination on semantic web-a perspective
Dinasarapu AR, Gupta S. (2014). "Biological data integration and dissemination on semantic web-a perspective." Journal of Bioinformatics and Intelligent Control. 3(4),273-277.
Statistical insights into major human muscular diseases.
Gupta S, Kim SM, Wang Y, Dinasarapu AR, Subramaniam S. (2014). "Statistical insights into major human muscular diseases." Hum Mol Genet. 23(14):3772-8.
A combined omics study on activated macrophages–enhanced role of STATs in apoptosis, immunity and lipid metabolism
Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass CK, Subramaniam S. (2013). "A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism." Bioinformatics. 29(21):2735-43.
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages.
Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. (2013). "Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages." J Lipid Res. 54(9):2525-42.
CMAP: Complement Map Database
Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. (2013). "CMAP: Complement Map Database." Bioinformatics. 29(21):2735-43.
MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling.
Dontula R, Dinasarapu A, Chetty C, Pannuru P, Herbert E, Ozer H, Lakka SS. (2013). "MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling." Genes Cancer. 4(7-8):285-96.
Bioinformatics and Systems Biology of the Lipidome.
Subramaniam S, Fahy E, Gupta S, Sud M, Byrnes RW, Cotter D, Dinasarapu AR, Maurya MR. (2011). "Bioinformatics and Systems Biology of the Lipidome." Chem Rev. 111(10):6452-90.
Signaling gateway molecule pages—a data model perspective
Dinasarapu AR, Saunders B, Ozerlat I, Azam K, Subramaniam S. (2011). "Signaling gateway molecule pages—a data model perspective." Bioinformatics. 27(12):1736-1738.
Comparative analysis of transcription start site using mutual information
Ashok Reddy D and Mitra C K. (2006). "Comparative analysis of transcription start site using mutual information." Geno. Prot. Bioinf.. 4(3), 183-195.
Functional classification of transcription factor binding sites: Information content as a metric
Ashok Reddy D, Prasad B V L S and Mitra C K. (2006). "Functional classification of transcription factor binding sites: Information content as a metric." Journal of Integrative Bioinformatics. 3(1), 0020.
Comparative analysis of core promoter region: Information content from mono and dinucleotide substitution matrices
Ashok Reddy D, Prasad B V L S and Mitra C K. (2006). "Comparative analysis of core promoter region: Information content from mono and dinucleotide substitution matrices." Comput Biol Chem. 30, 58-62.
Talks
Systems biology approach predicts immune-modulatory role of recreational marijuana use by HIV-infected young adults.
Invited talk at Systems biology and Bioinformatics interest group, Atlanta GA, USA
Alcohol and substance use in youth living with HIV-1 and anti- retroviral therapy modulates anti-viral response through immune cell- surface receptors.
Selected talk at College of Medicine Celebration of Research, Gainesville FL, USA
Whole blood transcriptome (bioinformatics) analysis of substance use by healthy and HIV+ human subjects.
Invited talk at 2014 Bioinformatics Seminar Series, Gainesville FL, USA
Analysis of Gene Regulatory Elements Using Mutual Information.
Invited talk at Department of Biology, Arlington TX, USA
Teaching
Conference committee member
- 2015 - NETTAB 2015 & Integrative Bioinformatics 2015 (Joint Symposium) Ruvo di Puglia (BA), Italy
- 2014 - International Symposium on Integrative Bioinformatics 2014, Newcastle University, UK
- 2013 - International Symposium on Integrative Bioinformatics 2013, IPK-Gatersleben, Germany