Sutcliffe DJ*, Dinasarapu AR *, Visser JE, Hoed JD, Seifar F, Joshi P, Ceballos-Picot I, Sardar T, Hess EJ, Sun YV, Wen Z, Zwick ME, Jinnah HA (2021) Induced Pluripotent Stem Cells from Subjects with Lesch-Nyhan Disease" Scientific Reports 11, 8523 (2021)
- Ph.D. Biochemistry/Bioinformatics, University of Hyderabad, India 2007
- M.Tech. Biotechnology, Anna University, India 2002
- M.Sc. Biochemistry, University of Hyderabad, India 2000
- B.S. Chemistry & Biology, Andhra Loyola College, India 1997
- 10/2017-till: Scientist, Bioinformatics
- 09/2015-10/2017: Bioinformatics Analyst, Sr
- Emory University, Atlanta
- Duties included: Genomic data analysis
- Supervisors: Bali Pulendran Ph.D &
- 11/2013-09/2015: Postdoctoral Associate
- University of Florida, Gainesville
- Duties included: Microarray data analysis
- 03/2008-11/2013: Postdoctoral Fellow
- University of California San Diego
- Duties included: Microarray and Lipidomic data analysis
- NGS, Proteomic and Metabolomic data analysis
- Cluster and Cloud computing
- Linux shell
Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease.
Chakravorty S, Berger L, Rufibach L, Gloster L, Emmons A, Shenoy S, Hegde M, Dinasarapu AR, Gibson G (2021) Combinatorial clinically driven blood biomarker functional genomics significantly enhances genotype-phenotype resolution and diagnostics in neuromuscular disease." medRxiv
Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.
Briscione MA, Dinasarapu AR, Bagchi P, Donsante Y, Downs AM, Fan X, Hoehner J, Jinnah HA, Hess EJ (2021). "Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders." bioRxiv
Kilic-Berkmen G, Scorr L, Dinasarapu AR, McKay L, Rosen A, Bagchi P, Hanfelt J, McKeon A, Jinnah HA (2020) Autoimmune and Inflammatory Mechanisms in Cervical Dystonia." medRxiv
Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).
Nabil F. Saba NF*, Dinasarapu AR*, Magliocca KR, Dwivedi B, Seby S, Qin ZS, Patel M, Griffith CC, Wang X, El-Deiry M, Steuer CE, Kowalski J, Shin DM, Zwick ME, Chen ZG (2020). "Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)." PLOS ONE 15(9): e0238497.
Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.
Verma A, Schmidt B, Nguyen N, Elizaldi S, Walter K, Beck Z, Trinh H, Dinasarapu AR, ... and Iyer SS. (2020). "Impact of Th1 CD4 TFH skewing on antibody responses to an HIV-1 vaccine in Rhesus Macaques." Journal of Virology, 94 (6) e01737-19.
Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques.
Elizaldi SR, Verma A, Walter KA, Rolston M, Dinasarapu AR, Durbin-Johnson BP, Settles M, Kozlowski PA, Raeman R and Iyer SS. (2019). "Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques." mSphere, 4:e00824-19.
Dinasarapu AR, DJ Sutcliffe, ME Zwick, HA Jinnah. (2018). "Modeling DYT1 Dystonia Using Induced Pluripotent Stem Cells." Annals Of Neurology, 84, S198-S199.
Sutcliffe D, Dinasarapu A, Zwick M, Jinnah H (2018). "Disease Modeling of Lesch-Nyhan Disease Using Induced Pluripotent Stem Cells." MOVEMENT DISORDERS, 33.
Dinasarapu AR, Gupta S. (2014). "Biological data integration and dissemination on semantic web-a perspective." Journal of Bioinformatics and Intelligent Control. 3(4),273-277.
Gupta S, Kim SM, Wang Y, Dinasarapu AR, Subramaniam S. (2014). "Statistical insights into major human muscular diseases." Hum Mol Genet. 23(14):3772-8.
A combined omics study on activated macrophages–enhanced role of STATs in apoptosis, immunity and lipid metabolism
Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass CK, Subramaniam S. (2013). "A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism." Bioinformatics. 29(21):2735-43.
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages.
Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. (2013). "Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages." J Lipid Res. 54(9):2525-42.
Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. (2013). "CMAP: Complement Map Database." Bioinformatics. 29(21):2735-43.
Dontula R, Dinasarapu A, Chetty C, Pannuru P, Herbert E, Ozer H, Lakka SS. (2013). "MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling." Genes Cancer. 4(7-8):285-96.
Subramaniam S, Fahy E, Gupta S, Sud M, Byrnes RW, Cotter D, Dinasarapu AR, Maurya MR. (2011). "Bioinformatics and Systems Biology of the Lipidome." Chem Rev. 111(10):6452-90.
Dinasarapu AR, Saunders B, Ozerlat I, Azam K, Subramaniam S. (2011). "Signaling gateway molecule pages—a data model perspective." Bioinformatics. 27(12):1736-1738.
Ashok Reddy D and Mitra C K. (2006). "Comparative analysis of transcription start site using mutual information." Geno. Prot. Bioinf.. 4(3), 183-195.
Ashok Reddy D, Prasad B V L S and Mitra C K. (2006). "Functional classification of transcription factor binding sites: Information content as a metric." Journal of Integrative Bioinformatics. 3(1), 0020.
Comparative analysis of core promoter region: Information content from mono and dinucleotide substitution matrices
Ashok Reddy D, Prasad B V L S and Mitra C K. (2006). "Comparative analysis of core promoter region: Information content from mono and dinucleotide substitution matrices." Comput Biol Chem. 30, 58-62.
Systems biology approach predicts immune-modulatory role of recreational marijuana use by HIV-infected young adults.
Invited talk at Systems biology and Bioinformatics interest group, Atlanta GA, USA
Alcohol and substance use in youth living with HIV-1 and anti- retroviral therapy modulates anti-viral response through immune cell- surface receptors.
Selected talk at College of Medicine Celebration of Research, Gainesville FL, USA
Whole blood transcriptome (bioinformatics) analysis of substance use by healthy and HIV+ human subjects.
Invited talk at 2014 Bioinformatics Seminar Series, Gainesville FL, USA
Invited talk at Department of Biology, Arlington TX, USA
Conference committee member
- 2015 - NETTAB 2015 & Integrative Bioinformatics 2015 (Joint Symposium) Ruvo di Puglia (BA), Italy
- 2014 - International Symposium on Integrative Bioinformatics 2014, Newcastle University, UK
- 2013 - International Symposium on Integrative Bioinformatics 2013, IPK-Gatersleben, Germany