A combined omics study on activated macrophages–enhanced role of STATs in apoptosis, immunity and lipid metabolism
Published in Bioinformatics, 2013
Recommended citation: Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass CK, Subramaniam S. (2013). "A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism." Bioinformatics. 29(21):2735-43. http://adinasarapu.github.io/files/btt469.pdf
Macrophage activation by lipopolysaccharide and adenosine triphosphate (ATP) has been studied extensively because this model system mimics the physiological context of bacterial infection and subsequent inflammatory responses. Previous studies on macrophages elucidated the biological roles of caspase-1 in post-translational activation of interleukin-1β and interleukin-18 in inflammation and apoptosis. However, the results from these studies focused only on a small number of factors. To better understand the host response, we have performed a high-throughput study of Kdo2-lipid A (KLA)-primed macrophages stimulated with ATP.