Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.

Published in as Research Square Preprints, 2022

Recommended citation: Hawes CE, Elizaldi SR, Beckman D, Diniz GB, Lakshmanappa YS, Ott S, Durbin-Johnson BP, Dinasarapu AR , Gompers AL, Morrison JH, Iyer SS (2022). Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection (UNDER REVIEW). https://doi.org/10.21203/rs.3.rs-1701344/v1

Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progressive neurodegeneration and cognitive decline. Establishment of HIV-1 in the CNS early following infection underscores the need to delineate features of acute CNS immune activation as these early in ammatory events may mediate neurodegenerative processes.