Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.
Published in Journal of Neuroinflammation, 2022
Recommended citation: Hawes CE, Elizaldi SR, Beckman D, Diniz GB, Lakshmanappa YS, Ott S, Durbin-Johnson BP, Dinasarapu AR , Gompers AL, Morrison JH, Iyer SS (2022). Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection. Journal of Neuroinflammation, 19, 250. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02610-y
Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progressive neurodegeneration and cognitive decline. Establishment of HIV-1 in the CNS early following infection underscores the need to delineate features of acute CNS immune activation as these early in ammatory events may mediate neurodegenerative processes.