Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques.
Published in mSphere, 2019
Recommended citation: Elizaldi SR, Verma A, Walter KA, Rolston M, Dinasarapu AR, Durbin-Johnson BP, Settles M, Kozlowski PA, Raeman R and Iyer SS. (2019). "Rectal microbiome composition correlates with humoral immunity to HIV-1 in vaccinated rhesus macaques." mSphere, 4:e00824-19. http://adinasarapu.github.io/files/mSphere-2019.pdf
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood. Here, we examined the pivotal relationship between the mucosal microbiome and vaccine-induced immune responses by assessing longitudinal changes in vaginal and rectal microbiome profiles following intradermal immunization with an HIV-1 DNA vaccine in adult rhesus macaques that received two prior DNA primes.