Exploration of potential immune mechanisms in cervical dystonia

Published in Parkinsonism & Related Disorders, 2024

Recommended citation: Scorr LM, Kilic-Berkmen G, Sutcliffe DJ, Dinasarapu AR , McKay JL, Bagchi P, Powell MD, Boss JM, Cereb N, Little M, Gragert L, Hanfelt J, McKeon A, Tyor W, Jinnah HA (2024) Exploration of potential immune mechanisms in cervical dystonia. Parkinsonism & Related Disorders (2024) https://doi.org/10.1016/j.parkreldis.2024.106036

Screens for anti-neuronal antibodies did not reveal any obvious abnormalities. Plasma proteomics pointed towards certain abnormalities of immune mechanisms, and the multiplex assay pointed more specifically towards abnormalities in T lymphocytes. Abnormal immune cell frequencies were identified for some Cervical Dystonia (CD) cases, and these cases clustered together as a potential subgroup. Studies of HLA alleles indicated a possible association between CD and DRB1*15:03, which is reported to mediate the penetrance of autoimmune disorders.