Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line
Published in Stem Cells Translational Medicine, 2025
Recommended citation: Dinasarapu AR , Sutcliffe DJ, Ozel E, Thite A, Grychowski L, Visser JE, Hess EJ, Kolk SM, Jinnah HA, Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line, Stem Cells Translational Medicine, 14, 12, 2025. https://doi.org/10.1093/stcltm/szaf065
Induced pluripotent stem cells (iPSCs) are commonly used to model human genetic diseases. Two main strategies are used. The first involves making iPSC lines from individual cases with a disease, and the second involves making disease-relevant gene edits in established iPSC lines.